Summary :
⁣Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA), Lupus, and cancer. To understand the role of citrullination in pathophysiology, one needs to comprehensively identify the citrullinated proteins associated with these diseases and link them together. Towards this end, we used a chemoproteomic approach to define the RA-associated citrullinome. The identified proteins include numerous serine protease inhibitors (SERPINs) and serine proteases. Many of these serine proteases and SERPINs are involved in regulating hemostasis and fibrinolysis – the biological processes that maintain proper blood flow. The delicate balance between proteolytic and inhibitory reactions in hemostasis and fibrinolysis, can be disrupted, resulting in pathological conditions such as thrombosis and abnormal bleeding. Herein, we demonstrate that citrullination of P1-Arg containing SERPINs alters their activity under physiological conditions, thereby altering normal homeostasis. Overall, these data advance our understanding of the roles of citrullination in thrombosis and suggest that extracellular protein arginine deiminase (PAD) activity can modulate protease activity with consequent effects on SERPIN-regulated pathways.


About Author :
⁣Ronak Tilvawala received her bachelor’s degree in pharmaceutical sciences in 2007 from India. She received her PhD degree in chemistry in 2014 from Wesleyan University, USA. From 2014 to 2016, she worked as a postdoctoral fellow at Texas A & M medical school where she developed novel biosensors for the detection of early-stage tuberculosis. In 2016, she moved to UMass medical school, where she developed a novel chemoproteomic approach to detect citrullinated proteins from biological samples. In 2020, she joined the department of Molecular Biosciences at the University of Kansas as an Assistant Professor. The current projects are focused on mainly two areas: 1) understanding how protein citrullination disrupts the regulation of key protease cascades leading to thrombosis and inflammation in multiple pathologies; and 2) understanding how viral proteases interfere with host protease cascades to invade into the host system. She has co-authored more than 18 publications.

Summary :
⁣Neural circuits, composed of intercellular connected neurons with distinct properties lay the physical foundation of any brain function. Identifying subtype and connections of individual neurons in a circuit is the key to understand how information is processed and propagated in the brain. In order to obtain a detailed wiring diagram between neurons, we developed a series of multiplex labeling and profiling, sample preparation, and image processing tools to allow neuronal identity and connectivity features being directly measured by super-resolution light microscopy in a densely labeled mouse brain. Designed to be carried out with standard surgical, imaging and computational instrumentations, our comprehensive circuit mapping tool set will allow high-resolution, high-throughput neural circuit mapping in a regular neuroscience laboratory.


About Author :
⁣Dr. Cai’s overall passion is to combine biophysical approaches, imaging techniques, and computational tools to understand how complex neural circuits are formed in the brain. During his postdoctoral training, he successfully optimized a novel labeling technique, termed Brainbow, which uses the random expression of three or four fluorescent proteins to generate a unique color label for each neuron to decode and reconstruct densely labeled neuronal circuits. His lab focuses on using systems approaches to study the complex nervous system at the single cell resolution in Drosophila and mouse brains. His lab has been developing genetic labeling, imaging, circuit mapping, high-throughput single cell profiling, and computational tools to unambiguously label, identify and analyze thousands of neurons in the same brain.

Summary :
⁣In the realm of the Single-Molecule Electronics, a suite of advanced electrical characterization approaches have emerged allowing measuring charge transport in an electric contact made out of an individual molecule[1]. The field has (and is still) drawn(ing) an scenario where individual molecules can be chemically modified to deliver a particular electrical function in a nanoscale circuit, e.g. variable resistors[2], diodes[3], switches[4], etc. Along this excursion, we have observed that single molecules trapped in a nanoscale tunneling junction experience conformational structural changes and changes in molecule/ electrode contact geometries, which are usually accompanied by large conductance variations and can be easily detected electrically[1]. Such changes are induced by the imposed forces fields experienced by the molecules within the nanoscale gap, namely, a mechanical force and/or an electric field. In the past decade, we have learnt that under certain force field conditions, the individual molecules wired in a nanoscale junction undergo chemical transformations. Here, we will present a couple of illustrative examples of the use of singlemolecule junction to study and control reactivity at the nanoscale using electric fields, a concept that is inherent in the natural enzymatic molecular machinery.


About Author :
⁣Ismael Díez Pérez is currently a Professor at the Chemistry department of King’s College London (UK). He received a M.S. (2001) and a PhD in Chemistry (2006) from UB in the study of semiconductor/electrolyte interfaces. During this early career period, he developed novel approaches to study chemical reactions on electrode surfaces at the nanoscale exploiting electrochemical Scanning Probe Microscopes. Interested in adding chemical functionality to the electrode/liquid interface, he joined the group of NJ Tao in Arizona State University in 2007 as a postdoctoral research associate. At the beginning of this period, he won the prestigious International Outgoing Marie Curie fellowship (2008). His postdoctoral research was endorsed with a high record of publications (including several Nature publishing group papers) demonstrating original electrical effects in single-molecule devices.

Summary :
⁣The combination of lead halide perovskites nanocrystals (NCs) and conjugated polymer in a blend film opens the way to the realization of hybrid active layers with widely tunable optical and electrical properties, able to combine the best properties of both families. We investigated the emission properties of different polymer:perovskite NCs blends, evidencing that these hybrid films show photoluminescence spectra made by the linear superposition of the spectra of the components. This feature opens the way to the use of these blends as light emitting systems with broadly tunable emission color, including white emission. Moreover we investigated the interaction between the polymeric and the perovskite component, mainly unexplored to date, of a poly(9,9-dioctylfluoreneco- benzothiadiazole )(F8BT):CsPbI1:5Br1:5 nanocrystals hybrid film. We demonstrate that the primary interaction channel is charge transfer, both from F8BT to the NCs and from the NCs to F8BT, while Förster Resonant Energy Transfer has not visible effects, despite the excellent spectral overlap between F8BT emission and NCs absorption. Moreover we show that the charge transfer is assisted by energy migration within the F8BT excited states distribution and that it is dependent on the local micromorphology of the film. The possible relevance of our results for the development of hybrid organic-perovskite optoelectronic devices will be discussed.


About Author ;
⁣Marco Anni is Associate Professor of Experimental Physics at the University of Salento, Lecce (Italy). He graduated in Physics in 1998 and he obtained the title of Philosophy Doctor in Physics in 2001, both from the University of Lecce. From 2006 he heads the Photonic Laboratory of the Dipartimento di Matematica e Fisica “Ennio De Giorgi”. The research activity of the laboratory is focused on the investigation of the optical properties of innovative materials for applications in lasers, sensors and solar cells. He has authored more than 120 publications in international journals, two books and has co-authored 4 patents.

Summary :
⁣In this Keynote, I will present the recent achievements realized by my research group in the catalytic synthesis of heterocyclic derivatives by palladium-iodide promoted carbonylation processes. It will be shown how a simple catalytic system, consisting of PdI2 in conjunction with an excess of KI and in the absence of additional ligands, is able to promote a plethora of carbonylation reactions, including oxidative and substitutive carbonylations. Starting from CO and simple organic substrates (functionalized alkynes, in particular) as building blocks, these processes have allowed obtaining carbonylated heterocycles in one single synthetic step under relatively mild reaction conditions.


About Author :
⁣Prof. Bartolo Gabriele completed his PhD in “Chemical Sciences” in 1994 at the University of Calabria (Unical). In 1997 he joined Professor Ronald Breslow’s group at Columbia University (New York) for 1 year as a NATO-CNR fellow. In 1998 he returned to Unical, where he was promoted to Full Professor in 2006. His current scientific production includes more than 210 articles in international peer-reviewed journals [h-index: 48; total citations: 7048 (Scopus)] more than 10 chapters in international books, and 20 industrial patents. He received the “Research Award” in 2013 from the Italian Chemical Society, in the field Synthetic Organic Chemistry. His current research interests include the synthesis of high value added molecules by catalytic techniques and the development of new materials for advanced applications.

Summary :
⁣Fluorescence bioassay using responsive probes has been widely used in biomedical research and pre-/clinical investigations. The development of reliable bioanalytical probes for selective and sensitive detection of particular biomolecule in biological systems plays key roles in fluorescence bioassay and is essential for better understanding the roles of the biomolecule in their native contexts [1]. In the last two decades, a large number of fluorescent molecular probes have been developed for the detection of biomolecules in vitro and in vivo, while it remains challenge to use these probes for biomolecules detection in the samples with high background autofluorescence signals. In our research, we found that the optical output signals can be easily modulated to eliminate the autofluorescence signals via three strategies, including anti-Stokes upconversion luminescence [2], time-gated luminescence [3,4], and photoswitchable “double-checked” luminescence [5]. In this presentation, I will introduce our research using responsive molecule probes for accurate and background-free luminescence detection and imaging of reactive biomarkers in vitro and in vivo.


About Author :
⁣Dr. Run Zhang received his PhD from the Dalian University of Technology in 2012. He was a Postdoc Research Fellow at the Department of Physics and Astronomy in Macquarie University (MQ) in 2012, then a Macquarie University Research Fellow at the Department of Chemistry and Biomolecular Science in 2013-2015. He joined the Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, as a Research Associate in 2016. Here, he was awarded the Australian Research Council Discovery Early Career Researcher Award (ARC DECRA) Fellowship in 2017-2019 and is now a National Health and Medical Research Council (NHMRC) Emerging Leadership Fellow. He is a team leader of the biosensing and bioimaging, working on developing responsive molecules/nanomaterials for bioassay, imaging, early disease diagnosis and treatment. He has published more than 120 research papers since his first publication in 2010.

Summary :
⁣The decline of fossil fuels requires the expansion of renewable energy production. The use of wind and pv energy is associated with strong fluctuations that are insufficiently adapted to the demand. The use of storage systems can help to reduce the mismatch. While short-term storage systems such as batteries rely on charging and discharging cycles, long-term storage systems such as methanol storage can be charged and discharged over any time range. Current studies show a wide variety of possible applications for long-term storage systems based on methanol. Methanol can contribute to the decentralized supply of electricity, heat and fuel as well as to grid stabilization. In an emergency case, it can even supply entire consumer clusters autonomously for several days.


About Author :
⁣Edgar Harzfeld, Professor at Stralsund University. Studies and research in Leipzig and Zurich. Since 1996 at the Faculty of Electrical Engineering and Computer Science of Stralsund University responsible for electrical power supply and renewable energy systems. Since 2004 - 2022 numerous research projects on the subject of electrical energy storage technologies.

Summary :
⁣Accumulation of plastic products in the Environment that adversely affects wildlife, habitat of humans is a major concern for the government at present. As plastic is non-biodegradable in nature, it remain in environment for several years. As a result it is responsible for causing land, air and water pollution. Plastic pollution has been constantly damaging our sustainable environment. The production of plastic is increasing since 1950, 8.3 billion tones of plastic has been produced, which is likely to be double by 2050. The burning of plastic waste increase the risk of heart disease, damages the nervous system, respiratory ailments such as asthma and cause nausea or headaches. Hence, a sustainable step towards tomorrow’s greener and healthier environment needs immediate attention of the environmental scientists. Most of the environmental tools of plastics like cell phones, computers, helmets and hospital bags have molded society in many ways that make life both easier and safer. Plastic produced every year is used to make for single use, disposable packaging items or products when they are thrown out which damage the green environment. It is due to lack of self discipline and not worrying about future generations, selfish attitude and consumerist human has damaged the environment. It is the responsibility of educational institutions to sensitize and create public awareness. In addition to creating public awareness on the importance of a clean and healthy environment, plastic recycling facilities must be recommended. This invited talk will help the society to reduce their exposures to plastics and ensure the increase of healthy society with clean environment for the next future generations.


About Author :
⁣Dr. S. Ravichandran is currently working as an Associate Professor in Department of Chemistry at Lovely Professional University, Jalandhar, Punjab(INDIA). He completed his Ph.D. in 2006 from Madurai Kamaraj University, Madurai (Tamilnadu) and M.Sc. from Pondicherry University, Pondicherry. He has qualified in GATE with a score of 95 percentile conducted by Ministry of Human Research and Development in the year 1998. He has 17 years of Research experience and published 112 International papers. He has published 5 Textbooks and received Bharat Shiksha and Life Time Education Excellence National awards from Global society in New Delhi. His area of research work are: Synthesis of Mannich and Schiff bases with metal ions like Cu(II), Co(II), Ni(II) and Zn (II). Structural characterization using spectroscopic techniques like UV-Vis., IR, 1H NMR, CV, Chromatography and EPR. His current interest is to focus on the development of novel greener methodology for a Sustainable Development.

Summary : ⁣With the growing demand for alternative energy (especially plant biomass) and to avoid competition with traditional food crops, part of the less-favored areas may be used for energy crops. LAMMC Vėžaičiai branch (Lithuania) has been conducting research on 2 perennial fast-growing plant species (herbaceous and woody) in the acidic whitish soils (pH 4.2-4.4) of Western Lithuania since 2009 and 2014. The effect of liming (to adjust the optimal soil pH level) and nitrogen fertilizers on biomass growth was investigated. The increase in dry weight of cocksfoot (Dactylis glomerata L.), reed canary grass (Phalaris arundinacea L.) and common osier (Salix viminalis L.) was directly related to nitrogen fertilization alone. Liming and fertilization with nitrogen fertilizers and their interaction had a positive effect on the productivity of the following plants: black poplars (Populus nigra L.), cup plact (Silphium perfoliatum L.), virginia mallow (Sida hermaphrodita Rusby). Except for virginia mallow, the effect of liming on other plants is more pronounced only in the first few years of plant growth. However, primary soil liming had a positive effect on soil chemical parameters (especially humus growth) and microbiological activity.


About Author :
⁣Dr. Gintaras Šiaudinis is a scientific worker since 2007. The main interest of research: energy crops; their adaptivity under local soil and climatic conditions; plant biomass conversion to biofuels. The author has publisher 19 scientific publications in magazines indexed in Clarivate Analytics Web of Science database.

Summary :
⁣The IDUA gene (MIM 252800) provides instructions for producing alpha-Liduronidase, which is essential for the breakdown of large sugar molecules called glycosaminoglycans (GAGs). Mutations in the IDUA gene have been found to cause mucopolysaccharidosis type I (MPS I) (MIM 607014). This leads to the accumulation of GAGs within lysosomes causing many different organs and tissues to be dysfunctional. Deleted IDUA gene has not been reported in literatures which showed to be associated with severe phenotype in our proband case.


About Author :
⁣Nuha Alzaabi is Metabolic genetic physician working currently in Fujairah Hospital. She has finished her MBBS from UAE university. Then She joined Pediatric Arab board residency program in Fujairah Hospital and finished in 2015. She Had also MRCPCH. In 2015, she joined biochemical genetic fellowship in United Arab University and finished in 2018. Currently she is working as metabolic genetic consultant in Fujairah hospital in UAE and as a program director for pediatric Arab board residency program.

Summary :
⁣The face is the center of our organism, responsible for communication, feeding, breathing, and the development of different senses. In the baby, it is essential to the satisfaction of the oral phase, swallowing, speech, hearing, eye contact, and establishing a relationship with the environment around us. Each day it becomes more frequent to use ventilation masks from an early age for reasons related to the development and maintenance of life in many children. Masks are an essential instrument capable of saving lives at certain critical times and allowing it to be maintained at other times. The use of masks requires a lengthy application time, which results in forces with possible harmful effects on the structures involved. The younger the child, the more bones and tissues are deformable by external stimuli. This means that whenever any force is applied to the skull bones, a reaction to that force is expected, so the design of the masks should be adapted to each face whenever possible and have support at more rigid and less deformable points to prevent deformities, taking into account the place where the type of force operates, direction and intensity, in addition to the time of action of the force. Any deformity can result in organ dysfunction, interfere with development, sleep, and learning, and have huge repercussions on the whole family’s life. A pediatric dentist is an essential element in the medical team that follows these patients and should always identify, prevent, and intercepts these problems to achieve proper development.


About Author :
⁣Degree in Medicine in 1991. Postgraduation in Orthodontics at the European Orthodontics Centre (1988), Postgraduation in Patients with Neurological Deviations at Fundación Sonnenschein (1997), Postgraduation in - Patient Management with Intravenous Sedation and Nitrogen Protoxide Sedation in General Dentistry (New York, 1998), and Postgraduation in Orthodontics (New York University, 2000). Ph.D. in Pediatric Dentistry and Orthodontics in 2000. Currently, he is the Director of the Specialization Program in Pediatric Dentistry at FMDUP (180 ECTS). Developing P2LINK Project with Lisbon Baby Lab– Fundação para a ciência e tecnologia.

Summary :
⁣Overt and subclinical maternal infections in pregnancy can have multiple and significant pathological consequences for the developing fetus, leading to acute perinatal complications and/or chronic disease throughout postnatal life. The current concept of pregnancy as a state of systemic immunosuppression seems oversimplified and outdated. In pregnancy the maternal immune system undergoes complex changes to establish and maintain tolerance to the fetus while still protecting from pathogens. In addition to downregulated maternal immunity, hormonal changes, and mechanical adaptation make the pregnant woman more susceptible to respiratory pathogens, such as influenza virus, respiratory syncytial virus (RSV), and severe acute respiratory syndrome coronavirus-2 (SARSCoV- 2). Depending on the infectious agent and timing of the infection during gestation, fetal pathology can range from mild to severe, and even fatal. Influenza is associated with a higher risk of morbidity and mortality in pregnant women than in the general population, and, especially during the third trimester of pregnancy, mothers are at increased risk of hospitalization for acute cardiopulmonary illness, while their babies show higher risk of complications such as prematurity, respiratory and neurological illness, congenital anomalies, and admission to neonatal intensive care.


About Author :
⁣MD, Pediatrician, PhD, University Resercher at Pediatric Unit, Dept of Human and Pediatric Pathology “Gaetano Barresi”, University of Messina, Messina, Italy. She took National habilitation (ASN) as Full Professor in Pediatrics; National habilitation (ASN) as Associate Professor in Pediatrics; PhD in “Biotechnology in Medicine and Surgery”, University of Messina, Messina, Sicily, Italy; Doctor Europeaus in “Biotechnology in Medicine and Surgery”, University of Messina, Messina, Sicily, Italy. Her research experience is focused on pulmonology and allergology in the paediatric population.

Summary :
⁣Electroencephalography (EEG) remains the most important investigative modality in the diagnostic evaluation of individuals with encephalopathy. Children living with encephalopathies in the developing world are faced with challenges of lack of access to appropriate diagnostic evaluation and a high risk of misdiagnosis and inappropriate therapy. We appraised EEG studies in a cohort of libyan children with encepahlopathies seen in a tertiary center in order to evaluate access to and the impact of EEG in the diagnostic evaluation of the cases.


About Author :
⁣Saeed H. Ali, Assistant Professor, Faculty of Medicine , Tobruk University, Tobruk, Libya

Summary :
⁣Expand the testing of sensorimotor influences on infant speech perception to a novel phoneme contrast and beyond segmental phonology, including prosodic distinctions (> perception of word stress and intonation contrasts); Offer the first study on whether infants spontaneously move their tongue when listening to speech; Measure the relation between later language outcomes and the impact of sensorimotor influences on early speech perception; Design and test a pacifiershaped device that may be amply used in clinical populations to improve oral morphology, and that is validated from the auditory-motor perspective as not restricting perceptual abilities; Assess the benefits of the device both for oral morphology and language development through a longitudinal intervention study with infants with Down Syndrome. A series of studies of sensorimotor influences in typically developing 6- montholds. Combining cross-sectional and longitudinal designs, experimental online measures of auditory processing, tongue shape/movement, parental reports, and language assessment tools, and a longitudinal intervention study. The project will be presented in general form, and his preliminary results depending on the work done until the conference.


About Author :
⁣Degree in Medicine in 1991. Postgraduation in Orthodontics at the European Orthodontics Centre (1988), Postgraduation in Patients with Neurological Deviations at Fundación Sonnenschein (1997), Postgraduation in - Patient Management with Intravenous Sedation and Nitrogen Protoxide Sedation in General Dentistry (New York, 1998), and Postgraduation in Orthodontics (New York University, 2000). Ph.D. in Pediatric Dentistry and Orthodontics in 2000. Currently, he is the Director of the Specialization Program in Pediatric Dentistry at FMDUP (180 ECTS). Developing P2LINK Project with Lisbon Baby Lab– Fundação para a ciência e tecnologia.

Summary :
⁣Kawasaki disease, since its first description in the 60s of the 20th century, has always been of particular interest to pediatricians around the world, due to the ploimorphism of the clinical picture, unpredictable course and possible complications in the form of coronaritis, aneurysms of the coronary arteries and the possibility of an early debut of the lesion. hearts. Your attention is given to the case of Kawasaki disease in a 4-year-old girl. The child was transfused intravenous immunoglobulin once at a dose of 2 g/kg, after which the child received acetylsalicylic acid at a dose of 85 mg/kg/day (80-100 mg/kg/day). Against the background of ongoing treatment, there was a disappearance of fever and an unexpectedly rapid decrease in the manifestations of coronaritis - a decrease in the diameter of the coronary arteries, according to ultrasound of the heart. However, the first attempts to reduce the dose of acetylsalicylic acid, after 3 days of a feverfree period, to a maintenance dose of 3-5 mg/ kg/day, led to a relapse of fever. Considering this clinical picture, the child was re-administered acetylsalicylic acid in doses of 85 mg/kg/day, and then a decision was made to gradually reduce the dose of acetylsalicylic acid: 85 mg/kg/day - 50 mg/kg/day-25 mg/kg/day. day-5mg/kg/day. With this appointment, the recurrence of fever was not observed. The child was discharged home in a satisfactory condition. Control ultrasound examination after 2 weeks showed a significant regression of the diameters of the coronary arteries. Continues therapy with acetylsalicylic acid 5 mg / kg / day - an estimated duration of 12 weeks and continues to be regularly monitored by a pediatrician and cardiologist.


About Author :
⁣Dmytro Tokariev received a medical degree at the age of 23 from the Dnepropetrovsk State Medical Academy, Ukraine. He was a neonatologist at the Regional Neonatal Center, Dnipro, Ukraine, medical director of the research company Arensia Exploratory Medicine Ukraine., Kiev, Ukraine, pediatrician in Amel Dental Clinic, Dnipro, Ukraine. Now he is a head of Pediatric Department Children’s and Maternal Hospital named after Prof. M.F. Rudnev, Dnipro, Ukraine. He has publications devoted to the problems of neonatology, pediatrics, clinical genetics, in particular to the problems of CDG. He is the co-author (another author is Alexandr Kulikov) of the medical diagnostic program Neo Genetics (Interactive database including clinical information on more than 2,500 genetic syndromes with an innovative search engine using about 8,000 symptoms

Summary :
⁣In our country, the “Breast Milk Encouragement and Baby-Friendly Health Institutions Program” was started in 1991. This program, proposed by WHO and UNICEF, aims to transform all health institutions into baby-friendly health institutions to support breastfeeding. For this purpose, it is tried to ensure that every baby who comes to the world is introduced to the first breast milk. Many new features of breast milk, which is so miraculous, have been described. When both mother and baby are sick, the number of leukocytes increases 64 times in breast milk. But only baby is sick the number of leukocytes increases 13 times. Lactoferrin, an acute phase reactant, is increased in breast milk before the baby is sick. It is known that the baby gives the information that he will get sick from the mother’s breast with his saliva. It is known that if the baby has the FADS2 gene, s\he has a IQ 6.8 points higher than other children and the enzyme that activates this gene is found in breast milk. Breast milk provides an ideal nutritional feature for the microbiota in our intestines, which is the second brain of our body. Despite so many new features of breast milk, the number of breastfed babies is still not at the desired level. In order to create healthy generations, we must work to increase the number of breastfed babies.


About Author :
⁣As of 2010, I started to work on breast milk and breastfeeding consultancy. As of 2010, I started to work as a field supervisor and trainer of “National Baby-Friendly Health Programs” under the Ministry of Health of Turkiye. For nearly 12 years, I have evaluated many hospitals and primary health care institutions in Turkey with this perspective. For 1.5 years, I have evaluated immigrant health centers in many provinces in Turkey, especially in the south and southeast, in terms of baby-friendly health institutions, and I have provided consultancy services for them to participate in this formation. I supported the writing of the Turkish Ministry of Health’s breast milk breastfeeding counseling book according to the WHO’s baby-friendly health programs guide.

Summary :
⁣Severe allergic asthma in children has a relatively low prevalence among total number of asthma patients. The main goal of the long-term treatment is achieving disease control as defined by the guidelines. Current therapeutic options in allergic asthma include several alternatives that offer the possibility to personalize the treatment in these severe forms. Omalizumab is a monoclonal antibody that binds and inhibits free serum immunoglobulin E. It is the first biological agent that was approved in children with severe allergic asthma. We present a series of patients treated with Omalizumab in the IIIrd Pediatric University Hospital In Cluj-Napoca, Romania over a period of 9 years. The main outcomes that we analyzed are the number an severeity of exacerbations, the presence of symptoms between exacerbations, pulmonary function tests and asthma control test (ACT).


About Author :
⁣Doctoral Degree in Medicine (2001): “Monitoring of treatment with theophylline administered in children with asthma and in prematures with idiopathic apnea by measuring salivary level of the drug”. Lecturer in Pediatrics (2002) at The University of Medicine and Pharmacy “Iuliu Hațieganu”, Dpt. 9, Disc. Pediatric III, Cluj Napoca Overspecialisation in Paediatric Pneumology Competence in “ Special Pulmonary Function Tests” Competence in Pediatric Allergology and Immunology Member of The Pediatric Pneumology Committee of the Ministry of Health (since 2019).

Summary :
⁣A large number of genetically determined diseases have phenotypic manifestations in the form a large number of small anomalies of development, resistant, convulsive syndrome, psychomotor developmental delay syndrome, which can be used in the diagnosis of these diseases, starting from neonatal period. In order to carefully analyze the phenotype was used a specially designed scale - the scale of phenotype analysis (SAF) The use of this scale for additional examination of a newborn made it possible to suspect, and subsequently verify genetically determined diseases in 20% of the examined children. Comprehensive phenotype research can be used to optimize the diagnosis of genetically determined diseases. Careful study of the phenotype allows to diagnose genetically determined conditions, starting from the newborn period. The use of a phenotype assessment scale is available a fairly simple, inexpensive method of diagnosis that does not require additional equipment and special training.


About Author :
⁣Dmytro Tokariev received a medical degree at the age of 23 from the Dnepropetrovsk State Medical Academy, Ukraine. He was a neonatologist at the Regional Neonatal Center, Dnipro, Ukraine, medical director of the research company Arensia Exploratory Medicine Ukraine., Kiev, Ukraine, pediatrician in Amel Dental Clinic, Dnipro, Ukraine. Now he is a head of Pediatric Department Children’s and Maternal Hospital named after Prof. M.F. Rudnev, Dnipro, Ukraine. He has publications devoted to the problems of neonatology, pediatrics, clinical genetics, in particular to the problems of CDG. He is the co-author (another author is Alexandr Kulikov) of the medical diagnostic program Neo Genetics (Interactive database including clinical information on more than 2,500 genetic syndromes with an innovative search engine using about 8,000 symptoms

Summary :
⁣Extravasation is a major problem especially among the pediatric population. Extravasation is defined as infiltration or leakage of an intravenous chemotherapeutic agent into the surrounding tissue which results in local damage.The various types of extravasation causing agents can be Sclerosing,fibrosing agents.Drugs that can cause blisters,ulceration, severe tissue destruction & necrosis. Eg.. Vincristine.or drugs that can cause burning and inflammation.eg.. Dacarbazine. Usually cause extravasation. Two major mechanisms are believed to cause tissue damage,DNA binding vesicant agents (e.g., anthracyclines) Absorbed by local cells in the tissue and bind to DNA,causing cell death.Non DNA binding vesicant agents (e.g., vinca alkaloids)These agents do not bind to cellular DNA.Local tissue damage is more easily neutralized than damage to surrounding tissues. Pediatric nurses play a major role in preventing extravasations occurring and also managing the extravasations on time to prevent complications which even can be fatal.The aim of this presentation is to high light the role of nurses in preventing and managing extravasations in the hospital.


About Author :
⁣Mary Anbarasi Johnson working as a professor and Head in pediatric nursing department ,CMC Vellore.I worked as Clinical Nurse Specialist in PICU for a year and as Assit Professor in USA for two years.I also worked in administration in nursing ,in Saudi Arabia Defence Sector. CMC gave me opportunity to be Master trainer for International Projects like GFATM ,IMNCI at national level aswell national projects like ICMR Infection control ,Child Sexual Abuse Protection ,OSCE by Dr.MGR Medical university aswell Diabetic Educators programme etc. It also gave me opportunity to be examiner or paper setter for various levels of nursing students for 6 universities and inspector for Dr.MGR Medical University .I am very much interested in reviewing articles.I have published in 70 national , international journals and presented in around 30 national and international conferences. I have also contributed for 5 book chapters and is working on publishing a book soon. I have served in CMC Vellore as addl.Deputy Nurisng Superintendent for staff training and quality assurance aswell in CMC Instituitional research board as a member for a term of 4 years.I am reviewer or editorial member or advisory member in more than 50 international journals.I am also a reciepient of President”s Gold medal for standing first in the university for Bsc.N programme .I give all thanks to Lord Jesus Christ who is the reason for my living.I am indepted to my family ,teahcers and friends for their encouragement and support and particularly to CMC Vellore which has mentored me.