Marantodes pumilum (Kacip Fatimah) improves RANK/ RANKL/OPG pathway | Nelli Giribabu

Summary :
⁣M. pumilum has been claimed to protect the bone against the adverse effect of estrogen deficiency. Additionally, it also exhibits anti-diabetic activity. In view of these, this study aims to identify the mechanisms underlying the bone protective effect of M. pumilum in the presence of both estrogen deficiency and diabetes mellitus (DM). Methods: Ovariectomized, diabetic female rats were given M. pumilum leave aqueous extract (MPLA) (50 and 100 mg/kg/day), estrogen, glibenclamide and estrogen plus glibenclamide for 28 consecutive days. At the end of the treatment, fasting blood glucose (FBG), serum insulin, Ca2+, PO4 3- and bone alkaline phosphatase (BALP) levels were measured. Rats were sacrificed and femur bones were harvested for determination of expression level and distribution of RANK, RANKL, OPG and oxidative stress and inflammatory proteins by molecular biological techniques.

About Author :
⁣Dr. Giribabu Nelli, Senior Lecturer in the Department of Physiology, Faculty of Medicine, University of Malaya. In 2011 November, Dr. Giribabu Nelli completed his Ph.D. in reproductive and developmental biology at the Department of Zoology, Sri Venkateswara University, Tirupati, India. From 2013 to 2016, he worked as a postdoctoral fellow at the Department of Physiology, Faculty of Medicine, the University of Malaya. In the same Department, he was recruited as a Senior Lecturer in November 2016. He has now published 61 ISI publications with a high impact factor, as well as two book chapters and two patents (Filed) with achieved 6 grants. His main research interests on diabetes and their complications, obesity, natural products and male and female reproductive physiology.